Erchonia® Veterinary Lasers: Expand Treatment Range, Improve Outcomes, Get Results Fast

All studies carried out to obtain FDA-clearance are double blind, randomised, placebo-controlled, and multi-site – the most credible research in the market.

The following list shows the clinical trials and an outline of their progress. As a company, to protect our intellectual assets, not all clinical trials we are involved with are made public so as to maintain our competitive advantage. As such, not all clinical trials are listed below.

Please note: There are hundreds of clinical studies confirming the effectiveness of Low-Level Laser Therapy (LLLT), and every year there are many new publications. Below is a list of Erchonia-specific studies for FDA-clearance.

1) Equine Wound Healing – 2011 — Sponsor, placebo controlled, clinical study.
Study completed from Feb. 2011-April 2011.
Monitored by Hank Jann, DVM, MS, DAVCS from Oklahoma State University.

2) Equine Wound Healing – 2011 — Sponsor, Case Study.
Study completed from Nov. 2010-March 2011.
Monitored by Hank Jann, DVM, MS, DACVS from Oklahoma State University.

3) Market Clearance for Relief of Chronic Musculoskeletal Pain (FX 635) — 2019 — A collection of placebo-controlled, randomized, double-blind, parallel-group, multi-center clinical studies.
FDA-clearance – K190572

4) Market Clearance to Treat Chronic Low Back Pain (FX 635) — 2018 — Placebo-controlled, randomized, double-blind, parallel-group, multi-center clinical study.
FDA-clearance – K180197
To view NIH clinical trial records, click here.

5) Erchonia EVRL (EVRL) – 2016
a. while using the red diode, for adjunctive use in providing temporary relief of minor chronic neck and shoulder pain of musculoskeletal origin.
b. and while using the violet diode, to treat dermatological conditions, and specifically indicated to treat moderate inflammatory Acne Vulgaris.
FDA-clearance – K152196

6) Adjunct to Chronic Heel Pain Arising from Plantar Fasciitis Using the Erchonia FX635 Laser — 2012 — Sponsor and monitor, IRB approved, double blind, placebo controlled, multi-site, clinical study.
FDA-clearance – K132940
Study results published in the American Orthopaedic Foot & Ankle Society April 2014
To view NIH clinical trial records, click here.

7) Pain Associated With Breast Augmentation Surgery / Low-Level Laser — 2007 — Sponsor and monitor, IRB approved, double blind, placebo controlled, multi-site, clinical study.
Results used to obtain FDA-clearance – K072206
To view NIH clinical trial records, click here.

8) Acne Vulgaris — Dermatological Conditions / Low-Level Laser — 2005 — Sponsor and monitor, IRB approved, double blind, placebo controlled, multi-site, clinical study.
FDA-clearance – K050672

9) Low-Level Laser Light Therapy as an Aid to Liposuction and Reduction of Pain Associated With Surgery — 2004 — Sponsor and monitor, IRB approved, double blind, placebo controlled, multi-site, clinical study.
Study results used to obtain FDA-clearance – K041139
To view NIH clinical trial records, click here.

10) Chronic Neck and Shoulder Pain / Low-Level Laser — 2001 — Sponsor and monitor, IRB approved, double blind, placebo controlled, multi-site, clinical study.
Study results used to obtain FDA-clearance – K012580
To view NIH clinical trial records, click here.

11) Chronic Neck and Shoulder Pain / Low-Level Laser — 2000 — Sponsor and monitor, IRB approved, double blind, placebo controlled, multi-site, clinical study.
First study done in support of 510(k) submission, second study requested by FDA.

While the benefits of Low-Level Laser Therapy have been observed in hundreds of medical studies, the exact mechanisms that lead to these results are still being explored. Although we still have a lot to learn about the effects of light energy on different types of cells, the leading theory is that LLLT generates therapeutic effects through stimulating and enhancing specific biochemical processes within cells. Intuitively speaking, laser energy activates a key enzyme in our cells’ powerhouses (mitochondria), boosting energy production and cellular activity. This process enhances cell function, aids in cell repair and growth, and supports overall cellular health, leading to improved healing and regeneration.

More specifically, utilising the first law in photochemistry (Grotthuss-Draper law), laser energy is transferred to cytochrome c oxidase (CcO) – a respiratory energy-transducing enzyme which is involved in the electron transport chain in mitochondria. This energy transfer causes photodissociation of inhibitory nitric oxide from CcO, leading to an enhancement of enzyme activity, electron transport, mitochondrial respiration, and adenosine triphosphate (ATP) production. Consequently, by altering the cellular redox state, LLLT induces the activation of numerous intracellular signalling pathways, and alters the affinity of transcription factors concerned with cell proliferation, survival, repair, and regeneration.

With regard to the specific wavelengths used in Erchonia® devices, the primary wavelengths are red (635nm), green (520nm), and violet (405nm). Each wavelength offers distinct benefits and mechanisms of action, which can be summarised as follows:

1. Red Light (e.g. 635nm) – Pain Relief, Tissue Repair & Nail Fungus Treatment: Red light is optimal for stimulating Complex IV of the electron transport chain, enhancing ATP (cellular energy) production. This leads to accelerated tissue repair, reduced inflammation, and improved immune function via increased Interleukin-10 (IL-10). It is widely used for musculoskeletal pain relief, wound healing, and nerve regeneration. Additionally, red light plays a role in treating fungal nail infections, working in combination with violet light to promote an antifungal response​.
2. Green Light (e.g. 520nm) – Fat Loss, Collagen Production & Cellular Regeneration: Green light uniquely stimulates Complex III, supporting stem cell activation, collagen synthesis, and chondrocyte function. It has been FDA-cleared for pain and inflammation reduction and is particularly effective in fat loss treatments. The current theory also suggests that green light helps create transient pores in fat cells (adipocytes), allowing lipids to be released and metabolised naturally through the lymphatic system. Unlike fat freezing techniques that eliminate fat cells, green laser therapy encourages them to function like healthy, lean cells, restoring proper metabolic signalling​.
3. Violet Light (e.g. 405nm) – Antimicrobial, Scar Tissue Repair & Nail Fungus Treatment: Violet light has the highest photon energy per wavelength, making it uniquely effective for Complexes I and II of the mitochondria. It is particularly valuable for antimicrobial applications, helping to combat bacteria, fungi, and viruses. When used alongside red light, violet laser therapy enhances the body’s natural antifungal response by generating Reactive Oxygen Species (ROS) that convert into hydrogen peroxide, a natural antiseptic that kills fungal infections. This makes it an ideal treatment for onychomycosis (fungal nail infections)​.
4. Combining Wavelengths for Enhanced Results: By combining red, green, and violet wavelengths, treatments can target multiple biological pathways, improving pain relief, fat metabolism, immune response, and tissue regeneration. Clinical research has demonstrated that using a combination of these wavelengths leads to superior results compared to single-wavelength treatments​.

Erchonia® lasers utilise true laser technology, optimising photonic energy delivery through the use of monochromatic, collimated, and coherent beams of light. That is, the light emitted by a true laser is composed from photons that have the same wavelength (monochromatic), travel in the same direction / do not disperse (collimated), and are in phase in space and time (coherent). These three properties of true lasers make them the most effective and efficient devices within the Laser Therapy sector.

Erchonia® lasers were specifically designed to deliver the optimal amount of energy required to stimulate and enhance cell function while not damaging cells or producing painful heat sensations – all of our non-thermal LLLT devices are classified as ‘Class II Lasers’ by the FDA in virtue of their low output and very low risk of hazard.

Clinical studies and trials of Laser Therapy technologies indicate the following beneficial effects of Low-Level Laser Therapy (LLLT).

1. Anti-Inflammation. LLLT creates an anti-edema effect by dilating blood vessels and activating the lymphatic drainage system (which drains swollen areas). This reduces swelling caused by trauma or inflammation.
2. Anti-Pain (Analgesic). LLLT exerts a very beneficial effect on pain in multiple ways: It partially blocks neural transmission of pain signals to the brain; It decreases nerve sensitivity; It lessens pain by reducing edema; It helps to increase the production of high levels of painkilling chemicals such as endorphins, enkephalins, and opioids from the brain and adrenal gland.
3. Accelerated Tissue Repair and Cell Growth. Photons of light from lasers penetrate deeply into tissues and accelerate cellular reproduction and growth. The laser light also increases the energy available to the cell by increasing ATP production so that the cell can take on nutrients faster and get rid of waste products. As a result of exposure to laser light, all cells, including the cells of tendons, ligaments, and muscles, are repaired faster.
4. Improved Vascular Activity. LLLT significantly increases the formation of new capillaries in damaged tissue, which speeds up the healing process, closes wounds more quickly, and reduces scarring. LLLT also causes vasodilation – an increase in the diameter of blood vessels – which improves the delivery of blood and healing elements to damaged tissues.
5. Increased Metabolic Activity. LLLT stimulates higher outputs of specific pro-healing enzymes in blood cells, along with improved oxygen and nutrient delivery.
6. Trigger Points and Acupuncture Points. LLLT stimulates muscle trigger points and acupuncture points on a non-invasive basis, providing musculoskeletal pain relief.
7. Reduced Fibrous Tissue Formation. LLLT reduces the formation of scar tissue following damage from cuts, scratches, burns, or surgery.
8. Improved Nerve Function. Slow recovery of nerves in damaged tissue results in impaired sensory and motor function. LLLT speeds up the process of axonal regeneration and nerve cell reconnection, and increases the amplitude of action potentials to optimize muscle action.
9. Immunoregulation. LLLT directly affects immunity status by stimulating the production of immunoglobulins and lymphocytes, and by improving the ease of penetration of white blood cells into damaged tissue.
10. Faster Wound Healing. LLLT stimulates fibroblast development in damaged tissue. Fibroblasts are the building blocks of collagen, which is the essential protein required to replace old tissue or repair tissue injuries. As a result, LLLT is effective on open wounds and burns.

Erchonia® lasers are clinically proven to treat a wide range of veterinary conditions, including musculoskeletal pain, inflammation, non-healing wounds, post-surgical recovery, bone healing, neurological trauma, and chronic skin infections. They are safe for equine, canine, feline, and avian patients.

The efficacy of Erchonia® lasers has been scientifically proven with double blind, randomised, placebo-controlled, and multi-site studies. Many competing companies advertise their products as ‘clinically proven’, guaranteeing ‘instant results’. However, these claims are often not backed by comprehensive clinical evidence.

Several companies have FDA-clearance within the Laser Therapy sector, however, in most cases the intended use / indications of their products are quite limiting or not relevant to the marketed applications. Furthermore, these FDA-clearances are often obtained without any scientific research.

We always recommend that you ask for details of the FDA-clearances and make an informed decision. Pay particular attention to the scope of the clearance, whether it involved clinical studies, how many patients participated, were the studies placebo controlled, double blind, and randomised, how many peer reviewed published articles they have, and what the adverse reactions / side effects were – we would be happy to provide this information for you.

To understand the difference between the various types of Laser Therapy devices, it is first important to distinguish between High-Level Laser Therapy (HLLT) and Low-Level Laser Therapy (LLLT):

• HLLT devices are classified as ‘Class IV Lasers’ by the FDA in virtue of having a power output that’s greater than 500mW (i.e. high risk of hazard). The vast majority of HLLT devices have longer near-infrared wavelengths.
• LLLT devices are classified as either ‘Class IIIB Lasers’, ‘Class IIIR Lasers’, or ‘Class II Lasers’ in virtue of having a power output of 5-500mW, 1-5mW, or <1mW respectively (i.e. lower risk of hazard). The vast majority of LLLT devices have shorter wavelengths.

There is a common misconception, often propagated by the manufacturers of Class 4 Lasers, that high power with longer wavelengths results in:

1. Deeper penetration, allowing for the treatment of a wider range of conditions.
2. More efficacious results, due to the delivery of more energy into the cells.

This however, is not correct for the following well-documented reasons:

1. Laser light with wavelengths exceeding 950nm is highly absorbed by water, preventing much of its energy from penetrating the dermis. This strong absorption can also cause localised heating, leading to discomfort or pain, which may restrict its therapeutic application.
2. There is an optimal ‘dose’ of laser energy (typically 2-4 joules / cm²) required for therapeutic biostimulation. Deviating from this dose, either by providing significantly less or more energy, can be counterproductive. HLLT devices, with their substantial power outputs, risk surpassing this optimal range.
3. It is theorised that a minimum energy of 1.7eV per photon is required for therapeutic biostimulation via photochemical means – wavelengths exceeding 730nm cannot deliver this 1.7eV. As a result, HLLT devices, which often operate within these longer wavelengths, may not primarily function through inducing photochemical reactions. Instead, they might rely on alternative mechanisms, such as the therapeutic influence of localised heat generation. However, this approach may be less efficacious compared to biostimulation by photochemistry.

LLLT devices, on the other hand, aim to deliver energy via low output, short wavelength beams of light. The general theory is that this approach transfers the optimal amount of energy for stimulating and enhancing cell function, while not damaging cells or producing painful heat sensations.

Within the LLLT sector however, some of the higher output devices still generate heat / pain. Furthermore, many devices are advertised as ‘lasers’, when in fact they are Light Emitting Diodes (LEDs) or Superluminescent Diodes (SLDs). In contrast to LEDs or SLDs, ‘true’ lasers generate monochromatic, collimated, and coherent beams of light. These three properties of true lasers make them the most effective and efficient LLLT devices (c.f. ‘What Is the Technical Explanation for How Erchonia® Lasers Work?’ FAQ).

To separate Erchonia® from such technologies, and from HLLT more generally, we say that Erchonia® lasers are ‘non-thermal, true lasers’. That is, our lasers do not produce any heat or painful sensations, and are monochromatic, collimated, and coherent.

Yes. Erchonia® lasers are non-invasive, painless, and completely safe. Animals remain calm and fully awake during treatment. There is no downtime, and no reported adverse effects.

Erchonia® treatments are just 10-30 minutes long and are relaxing to administer, allowing you to take the pressure off your hands and body.

No prior laser experience is required. All purchases include comprehensive training, clinical protocols, and ongoing support to ensure confident, effective use from day one.

Yes. Erchonia® lasers are effective across species and adaptable for use in both mobile and in-clinic settings – ideal for equine, companion animal, and mixed practices.

Yes. All handheld Erchonia® veterinary lasers are cordless, lightweight (under 1 lb), and built with durable, medical-grade aluminium – perfect for both stationary use and field visits.

Absolutely. We offer full training, clinical support, marketing materials, and a dedicated team to help you integrate the technology, build protocols, and grow your practice.

Erchonia® lasers are used in many areas, such as 360-degree fat loss, body sculpting, cellulite reduction, pain management, pre / postsurgical healing, pre / rehabilitation, nail and skin pathologies (e.g. nail fungus and acne), and more.

The most effective, medical-grade devices for pain relief include XLR8®, EVRL®, GVL®, FX635®, FX405®, and Base Station. For fat reduction and body contouring, Emerald™, Verjú®, and VZ8 deliver exceptional results. The Lunula® Laser stands out as the only fully automated LLLT device FDA-cleared for fungal nail treatment. Each device is backed by robust clinical research and FDA clearances, ensuring the highest level of safety and efficacy​.